Disease severity and minimal clinically important differences in clinical outcome assessments for Alzheimer's disease clinical trials

Author:

Andrews J. Scott1,Desai Urvi2,Kirson Noam Y.2,Zichlin Miriam L.2,Ball Daniel E.1,Matthews Brandy R.1

Affiliation:

1. Eli Lilly and Company, Lilly Corporate CenterIndianapolisINUSA

2. Analysis Group, Inc.BostonMAUSA

Funder

National Institute on Aging

National Institutes of Health

Eli Lilly and Company

NIA

NIH

Publisher

Wiley

Subject

Psychiatry and Mental health,Clinical Neurology

Reference19 articles.

1. Systematic Review of Measures of Clinical Significance Employed in Randomized Controlled Trials of Drugs for Dementia

2. A point of minimal important difference (MID): a critique of terminology and methods

3. Measurement of health status

4. Green Park Collaborative Evidence guidance document: design of clinical studies of pharmacologic therapies for Alzheimer's disease Center for Medical Technology Policy.2013. Available at:http://www.cmtpnet.org/docs/resources/GPC_Evidence_Guidance_Document_‐_Alzheimers_Disease.pdf. Accessed September 10 2018.

5. L.Webster D.Groskreutz A.Grinbergs‐Saull R.Howard J.T.O'Brien andG.Mountain et al.Core outcome measures for interventions to prevent or slow the progress of dementia for people living with mild to moderate dementia: systematic review and consensus recommendations 2017. Available at:https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0179521 2017Accessed September 10 2018.

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