Design of a Bayesian adaptive phase 2 proof-of-concept trial for BAN2401, a putative disease-modifying monoclonal antibody for the treatment of Alzheimer's disease
Author:
Affiliation:
1. Neuroscience & General Medicine, Eisai Inc.; Woodcliff Lake NJ USA
2. Berry Consultants, LLC; Austin TX USA
Funder
Eisai, Inc., Woodcliff Lake, NJ, United States
Publisher
Wiley
Subject
Psychiatry and Mental health,Neurology (clinical)
Link
http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.trci.2016.01.001/fullpdf
Reference55 articles.
1. Alzheimer's disease drug-development pipeline: few candidates, frequent failures;Cummings;Alzheimers Res Ther,2015
2. Atorvastatin for the treatment of mild to moderate Alzheimer disease: preliminary results;Sparks;Arch Neurol,2005
3. Randomized controlled trial of atorvastatin in mild to moderate Alzheimer disease: LEADe;Feldman;Neurology,2010
4. A phase 2 multiple ascending dose trial of bapineuzumab in mild to moderate Alzheimer disease;Salloway;Neurology,2009
5. Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease;Salloway;N Engl J Med,2014
Cited by 58 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Pathways to personalized medicine—Embracing heterogeneity for progress in clinical therapeutics research in Alzheimer's disease;Alzheimer's & Dementia;2024-09-06
2. Food and Drug Administration (FDA) Approvals of Biological Drugs in 2023;Biomedicines;2024-09-02
3. Chemical signatures delineate heterogeneous amyloid plaque populations across the Alzheimer’s disease spectrum;2024-06-03
4. Lecanemab: A novel disease-modifying drug treatment for Alzheimer’s disease;National Journal of Pharmacology and Therapeutics;2024-05
5. A multimodal deep learning approach for the prediction of cognitive decline and its effectiveness in clinical trials for Alzheimer’s disease;Translational Psychiatry;2024-02-21
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3