A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects-Reference-Cited by-同舟云学术

A randomized controlled study to evaluate the effect of bexarotene on amyloid-β and apolipoprotein E metabolism in healthy subjects

Published:2016-06 Issue:2 Volume:2 Page:110-120
ISSN:2352-8737
Container-title:Alzheimer's & Dementia: Translational Research & Clinical Interventions
language:en
Short-container-title:Alzheimer's & Dementia: Translational Research & Clinical Interventions

Author:

Ghosal Kaushik¹,Haag Michael¹,Verghese Philip B.²,West Tim²,Veenstra Tim²,Braunstein Joel B.²,Bateman Randall J.³,Holtzman David M.³,Landreth Gary E.⁴

Affiliation:

1. ReXceptor LLC; Cleveland OH USA

2. C 2 N Diagnostics LLC; St. Louis MO USA

3. Department of Neurology; Washington University School of Medicine, Hope Center for Neurological Disorders, Knight Alzheimer's Disease Research Center; St. Louis MO USA

4. Department of Neurosciences; School of Medicine, Case Western Reserve University; Cleveland OH USA

Funder

Alzheimer Drug Discovery Foundation

BrightFocus Foundation

Eisai Pharmaceuticals

Case Western Reserve University

Brightfocus

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.trci.2016.06.001/fullpdf

Reference49 articles.

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3. Age and amyloid effects on human central nervous system amyloid-beta kinetics;Patterson;Ann Neurol,2015

4. Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks;Palop;Nat Neurosci,2010

5. APOE is a major susceptibility gene for Alzheimer's disease;Roses;Curr Opin Biotechnol,1994

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