The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates

Author:

Tsonkova Violeta Georgieva,Sand Fredrik Wolfhagen,Wolf Xenia Asbæk,Grunnet Lars Groth,Kirstine Ringgaard AnnaORCID,Ingvorsen Camilla,Winkel Louise,Kalisz Mark,Dalgaard Kevin,Bruun ChristineORCID,Fels Johannes Josef,Helgstrand Charlotte,Hastrup Sven,Öberg Fredrik Kryh,Vernet ErikORCID,Sandrini Michael Paolo Bastner,Shaw Allan Christian,Jessen Carsten,Grønborg Mads,Hald Jacob,Willenbrock Hanni,Madsen DennisORCID,Wernersson Rasmus,Hansson Lena,Jensen Jan Nygaard,Plesner Annette,Alanentalo Tomas,Petersen Maja Borup Kjær,Grapin-Botton AnneORCID,Honoré Christian,Ahnfelt-Rønne Jonas,Hecksher-Sørensen Jacob,Ravassard PhilippeORCID,Madsen Ole D.ORCID,Rescan Claude,Frogne Thomas

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference56 articles.

1. Beta-cell deterioration determines the onset and rate of progression of secondary dietary failure in type 2 diabetes mellitus: the 10-year follow- up of the belfast diet study;Levy;Diabetes Medicine,1998

2. Glucolipotoxicity of the pancreatic beta cell;Poitout;Biochimica et Biophysica Acta (BBA) – Molecular and Cell Biology of Lipids,2011

3. Human islet preparations distributed for research exhibit a variety of insulin-secretory profiles;Kayton;American Journal of Physiology –Endocrinology and Metabolism,2015

4. A genetically engineered human pancreatic β cell line exhibiting glucose-inducible insulin secretion;Ravassard;The Journal of Clinical Investigation,2011

5. Characterization of stimulus-secretion coupling in the human pancreatic EndoC-βH1 beta cell line;Andersson;PLoS One,2015

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