Single-cell transcriptomics of human islet ontogeny defines the molecular basis of β-cell dedifferentiation in T2D

Author:

Avrahami DanaORCID,Wang Yue J.,Schug Jonathan,Feleke Eseye,Gao Long,Liu Chengyang,Naji Ali,Glaser Benjamin,Kaestner Klaus H.ORCID

Funder

NIDDK-supported Human Islet Research Network

The BIRAX Regenerative Medicine Initiative

Israel Science Foundation (ISF)—Juvenile Diabetes Research Foundation Joint Program

EFSD/JDRF/Lilly Program

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference92 articles.

1. Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes;Butler;Diabetes,2003

2. Mechanisms of beta-cell death in type 2 diabetes;Donath;Diabetes,2005

3. Endoplasmic reticulum stress and type 2 diabetes;Back;Annual Review of Biochemistry,2012

4. Endoplasmic reticulum stress and pancreatic beta-cell death;Fonseca;Trends in Endocrinology and Metabolism,2011

5. Oxidative stress induces p21 expression in pancreatic islet cells: possible implication in beta-cell dysfunction;Kaneto;Diabetologia,1999

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