SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans-Reference-Cited by-同舟云学术

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SGLT2 is not expressed in pancreatic α- and β-cells, and its inhibition does not directly affect glucagon and insulin secretion in rodents and humans

Published:2020-12 Issue: Volume:42 Page:101071
ISSN:2212-8778
Container-title:Molecular Metabolism
language:en
Short-container-title:Molecular Metabolism

Author:

Chae Heeyoung^ORCID,Augustin Robert,Gatineau Eva,Mayoux Eric,Bensellam Mohammed,Antoine Nancy,Khattab Firas,Lai Bao-Khanh,Brusa Davide,Stierstorfer Birgit,Klein Holger^ORCID,Singh Bilal,Ruiz Lucie,Pieper Michael,Mark Michael,Herrera Pedro L.,Gribble Fiona M.,Reimann Frank,Wojtusciszyn Anne,Broca Christophe,Rita Nano,Piemonti Lorenzo,Gilon Patrick^ORCID

Funder

Actions de Recherche Concertées

Communauté Française de Belgique,

CDR

PDR

Fonds De La Recherche Scientifique - FNRS

Société Francophone du Diabète

European Foundation for the Study of Diabetes

Leona M. & Harry B. Helmsley Charitable Trust

Boehringer Ingelheim Pharma GmbH & Co. KG

Fonds de Recherche Clinique

MRC

Wellcome

NIH

Boehringer Ingelheim

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference52 articles.

1. Extraglycemic effects of SGLT2 inhibitors: a review of the evidence;Bonora;Diabetes Metabolic Syndrome Obesity,2020

2. Mechanisms of cardiorenal effects of sodium-glucose cotransporter 2 inhibitors: JACC state-of-the-art review;Zelniker;Journal of the American College of Cardiology,2020

3. Dapagliflozin improves muscle insulin sensitivity but enhances endogenous glucose production;Merovci;Journal of Clinical Investigation,2014

4. Renal, metabolic and cardiovascular considerations of SGLT2 inhibition;DeFronzo;Nature Reviews Nephrology,2017

5. The tubular hypothesis of nephron filtration and diabetic kidney disease;Vallon;Nature Reviews Nephrology,2020

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3. 100 years of glucagon and 100 more;Diabetologia;2023-06-27

4. Normal β-Cell Glut2 Expression Is not Required for Regulating Glucose-Stimulated Insulin Secretion and Systemic Glucose Homeostasis in Mice;Biomolecules;2023-03-16

5. BI 456906: Discovery and preclinical pharmacology of a novel GCGR/GLP-1R dual agonist with robust anti-obesity efficacy;Molecular Metabolism;2022-12

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