Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice-Reference-Cited by-同舟云学术

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Pnpla3 silencing with antisense oligonucleotides ameliorates nonalcoholic steatohepatitis and fibrosis in Pnpla3 I148M knock-in mice

Published:2019-04 Issue: Volume:22 Page:49-61
ISSN:2212-8778
Container-title:Molecular Metabolism
language:en
Short-container-title:Molecular Metabolism

Author:

Lindén Daniel^ORCID,Ahnmark Andrea,Pingitore Piero,Ciociola Ester,Ahlstedt Ingela,Andréasson Anne-Christine,Sasidharan Kavitha,Madeyski-Bengtson Katja,Zurek Magdalena,Mancina Rosellina M.^ORCID,Lindblom Anna,Bjursell Mikael,Böttcher Gerhard,Ståhlman Marcus,Bohlooly-Y Mohammad,Haynes William G.^ORCID,Carlsson Björn,Graham Mark,Lee Richard,Murray Sue,Valenti Luca^ORCID,Bhanot Sanjay,Åkerblad Peter,Romeo Stefano

Funder

Swedish Research Council

Swedish Heart-Lung Foundation

Swedish federal government

Novonordisk Foundation Grant

Swedish Diabetes Foundation

AstraZeneca

Knut and Alice Wallenberg Foundation

Wilhelm and Martina Lundgren Science Fund

Italian Ministry of Health

Publisher

Elsevier BV

Subject

Cell Biology,Molecular Biology

Reference49 articles.

1. Global epidemiology of nonalcoholic fatty liver disease-Meta-analytic assessment of prevalence, incidence, and outcomes;Younossi;Hepatology,2016

2. Definition and natural history of metabolic steatosis: clinical aspects of NAFLD, NASH and cirrhosis;Serfaty;Diabetes and Metabolism,2008

3. Increased risk of mortality by fibrosis stage in nonalcoholic fatty liver disease: systematic review and meta-analysis;Dulai;Hepatology,2017

4. Current and future therapeutic regimens for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH);Younossi;Hepatology,2018

5. Causal relationship of hepatic fat with liver damage and insulin resistance in nonalcoholic fatty liver;Dongiovanni;Journal of Internal Medicine,2018

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1. Sex‐specific effects of PNPLA3 I148M;Liver International;2024-09-11

2. Fibrosis and Hepatocarcinogenesis: Role of Gene-Environment Interactions in Liver Disease Progression;International Journal of Molecular Sciences;2024-08-08

3. PNPLA3(148M) promotes hepatic steatosis by interfering with triglyceride hydrolysis through a gain-of-function mechanism;2024-08-04

4. Use of PNPLA3, TM6SF2, and HSD17B13 for detection of fibrosis in MASLD in the general population;Clinics and Research in Hepatology and Gastroenterology;2024-08

5. Development of Therapy for Liver Fibrosis: Molecular/cellular basis and overcoming challenges;Kanzo;2024-07-01

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