Nucleophilic addition of indole-2-acetic ester enolates to N-alkylpyridinium salts. A formal synthesis of the strychnos alkaloids tubifolidine and tubifoline-Reference-Cited by-同舟云学术

Nucleophilic addition of indole-2-acetic ester enolates to N-alkylpyridinium salts. A formal synthesis of the strychnos alkaloids tubifolidine and tubifoline

Published:1990-01 Issue:35 Volume:31 Page:5089-5092
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Alvarez Mercades,Salas Marisa,de Veciana Anna,Lavilla Rodolfo,Bosch Joan

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference10 articles.

1. General method for the synthesis of bridged indole alkaloids. Nucleophilic addition of indoleacetic ester enolates to N-alkylpyridinium salts

2. M. Amat, A. Linares, and J. Bosch, J. Org. Chem., submitted.

3. First total synthesis and NMR data of the alkaloid 19,20-dihydroakuammicine

4. Carbon dioxide: a reagent for simultaneous protection of nucleophilic centers and the activation of alternative locations to electrophilic attack. V. Activation of the 2-alkyl group of a 2-alkylindole toward proton loss and subsequent electrophilic substitution

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