Conversion of 17O/18O labelled δ-(L-α-aminoadlpyl)-L-cysteinyl-D-valine to 17O/18O labelled isopenicillin n in a cell-free extract of . A study by 17O-NMR spectroscopy and mass spectrometry-Reference-Cited by-同舟云学术

Conversion of 17O/18O labelled δ-(L-α-aminoadlpyl)-L-cysteinyl-D-valine to 17O/18O labelled isopenicillin n in a cell-free extract of . A study by 17O-NMR spectroscopy and mass spectrometry

Published:1983-01 Issue:7 Volume:39 Page:1061-1068
ISSN:0040-4020
Container-title:Tetrahedron
language:en
Short-container-title:Tetrahedron

Author:

Adlington Robert M.,Aplin Robin T.,Baldwin Jack E.,Chakravarti Bulbul,Field Leslie D.,John Eeva-M.M.,Abraham Edward P.,White Robert L.

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference21 articles.

1. Incorporation of 3H from δ-(l-α-amino (4,5-3H)adipyl)-l-cysteinyl-d-(4,4-3H)valine into isopenicillin N

2. Cell-free conversion of δ-(l-α-aminoadipyl)-l-cysteinyl-d-valine into an antibiotic with the properties of isopenicillin N in Cephalosporium acremonium

3. Synthesis of δ-(α-aminoadipyl)cysteinylvaline and its role in penicillin biosynthesis

4. Direct n.m.r. observation of cell-free conversion of (L-α-amino-δ-adipyl)-L-cysteinyl-D-valine into isopenicillin N

5. Structural studies on penicillin derivatives. VIII. Possible model biosynthetic route to penams and cephems

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