Highly Diastereoselective Synthesis of 4-N-Methylformamidino Trinem (GV129606), a Potent Antibacterial Agent

Author:

Biondi Stefano,Pecunioso Angelo,Busi Filippo,Contini Stefania A,Donati Daniele,Maffeis Micaela,Pizzi Domenica A,Rossi Luciana,Rossi Tino,Sabbatini Fabio M

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference38 articles.

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2. Multiple drug resistance

3. Bush, K.; Mobashery, S. In Resolving the antibiotic paradox; Rosen, B. P., Mobashery, S., Eds.; Kluwer Academic/Plenum: New York, 1998.

4. (a) Biondi, S. Trinems: synthesis and antibacterial activity of a new generation of antibacterial β-lactams, Spec. Publ.—R. Soc. Chem., 1997; Vol. 198 (Anti-infectives), pp 86–100.

5. (b) Ghiron, C.; Rossi, T. The Chemistry of Trinems, Targets Heterocycl. Syst., 1997; Vol. 1, pp 161–186.

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