1. The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function
2. The structural requirement of phosphatidylinositols as substrate of phosphatidylinositol 3-kinase
3. PIP3 lipid analogs: (a) Sawada, T.; Shirai, R.; Matsuo, Y.; Kabuyama, Y.; Kimura, K.; Fukui, Y.; Hashimoto, Y.; Iwasaki, S. Bioorg. Med. Chem. Lett. 1995, 5, 2263–2266; (b) Sawada, T.; Shirai, R.; Iwasaki, S. Chem. Pharm. Bull. 1997, 45, 1521–1523; (c) Shirai, R.; Morita, K.; Nakatsu, N.; Fukui, Y.; Hashimoto, Y. Tetrahedron Lett. 1998, 39, 9485–9488; (d) Morisaki, N.; Morita, K.; Nishikawa, A.; Nakastsu, N.; Fukui, Y.; Hashimoto, Y.; Shirai, R. Tetrahedron 2000, 56, 2603–2614; (e) Morisaki, N.; Masaoka, M.; Shirai, Y.; Hashimoto, Y. Biol. Pharm. Bull. 2000, 23, 1088–1089.
4. PIP3 binding protein: (a) Tanaka, K.; Imajoh-Ohmi, S.; Sawada, T.; Shirai, R.; Hashimoto, Y.; Iwasaki, S.; Kaibuchi, K.; Kanaho, Y.; Shirai, T.; Terada, Y.; Kimura, K.; Nagata, S.; Fukui, Y. Eur. J. Biochem. 1997, 245, 512–519; (b) Shirai, T.; Tanaka, K.; Terada, Y.; Sawada, T.; Shirai, R.; Hashimoto, Y.; Nagata, S.; Iwamatsu, A.; Okawa, K.; Li, S.; Hattori, S.; Mano, H.; Fukui, Y. Biochim. Biophys. Acta 1998, 1402, 292–302; (c) Yokogawa, T.; Nagata, S.; Nishio, Y.; Tsutsumi, T.; Ihara, S.; Shirai, R.; Morita, K.; Umeda, M.; Shirai, Y.; Saito, N.; Fukui, Y. FEBS Lett. 2000, 473, 222–226; (d) Nishio, Y.; Nagata, S.; Umeda, M. Shirai, R.; Yokogawa, T.; Ihara, S.; Fukui, Y. Anal. Biochem. 2000, 285, 270–273.
5. Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesis