Synthesis of (E)-3-(2-carboxy-2-pyridyl-vinyl)-4,6-dichloro-1H-indole-2-carboxylic acids, glycine-site NMDA receptor antagonists, utilizing the Knoevenagel condensation reaction-Reference-Cited by-同舟云学术

Synthesis of (E)-3-(2-carboxy-2-pyridyl-vinyl)-4,6-dichloro-1H-indole-2-carboxylic acids, glycine-site NMDA receptor antagonists, utilizing the Knoevenagel condensation reaction

Published:2001-02 Issue:8 Volume:42 Page:1407-1409
ISSN:0040-4039
Container-title:Tetrahedron Letters
language:en
Short-container-title:Tetrahedron Letters

Author:

Cregge Robert J,Farr Robert A,Friedrich Dirk,Hulshof Jos,Janowick David A,Meikrantz Scott,Metz William A

Publisher

Elsevier BV

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference8 articles.

1. The Role of Glutamate Neurotoxicity in Hypoxic-Ischemic Neuronal Death

2. Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist

3. Use of Pseudoephedrine as a Practical Chiral Auxiliary for Asymmetric Synthesis

Cited by 6 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. A convenient synthesis of 3-formyl-2-thioacetamide-indole derivatives via the one-pot reaction of indolin-2-thiones, isocyanides and chloroacetylchloride;Tetrahedron Letters;2015-12

2. ChemInform Abstract: Synthesis of (E)-3-(2-Carboxy-2-pyridyl-vinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids, Glycine-Site NMDA Receptor Antagonists, Utilizing the Knoevenagel Condensation Reactions.;ChemInform;2010-05-26

3. Antagonists of AMPA/KA and NMDA (glycine site) glutamate receptors;Pharmaceutical Chemistry Journal;2008-02

4. Iminium Catalysis;Chemical Reviews;2007-12-01

5. CoMFA, Synthesis, and Pharmacological Evaluation of (E)-3-(2-Carboxy-2-arylvinyl)-4,6-dichloro-1H-indole-2-carboxylic Acids: 3-[2-(3-Aminophenyl)-2-carboxyvinyl]-4,6-dichloro-1H-indole-2-carboxylic Acid, a Potent Selective Glycine-Site NMDA Receptor Antagonist;Journal of Medicinal Chemistry;2005-02-01