Steric hindrance is a key factor in the coupling reaction of (acyloxy) alkyl-α-halides with phenols to make a new promoiety for prodrugs
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference18 articles.
1. Prodrugs of butyric acid from bench to bedside: Synthetic design, mechanisms of action, and clinical applications
2. Bisphosphonate Prodrugs: Synthesis and in Vitro Evaluation of Novel Acyloxyalkyl Esters of Clodronic Acid
3. Aqueous solubility and dissolution rate does not adequately predict in vivo performance: A probe utilizing some N‐acyloxymethyl phenytoin prodrugs
4. 3 Prodrug Design for Phosphates and Phosphonates
5. Application of Phase-Transfer Catalysis to the Synthesis ofO-Acylhemiacetals
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4. Synthesis and utility of fluorogenic acetoxymethyl ethers;Chem. Sci.;2011
5. ChemInform Abstract: Steric Hindrance is a Key Factor in the Coupling Reaction of (Acyloxy) Alkyl-α-halides with Phenols to Make a New Promoiety for Prodrugs.;ChemInform;2010-05-22
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