Regioselective synthesis of inhibitors of histone acetyl transferase covalently linking spermidine to the s-terminus of coenzyme a and fragments.
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference18 articles.
1. Inhibition of histone acetylation by N-[2-(S-coenzyme A)acetyl] spermidine amide, a multisubstrate analog.
2. Conditions for the self-catalysed inactivation of carnitine acetyltransferase. A novel form of enzyme inhibition
3. Synthesis of 2-bromoacetyl-SCoA
4. Darzens synthesis of glycidic thiol esters. Formation of a .beta.-lactone by-product
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1. Histone acetyltransferase inhibitors: An overview in synthesis, structure-activity relationship and molecular mechanism;European Journal of Medicinal Chemistry;2019-09
2. Synthesis and antikinetoplastid evaluation of bis(benzyl)spermidine derivatives;European Journal of Medicinal Chemistry;2018-04
3. Synthesis and in vitro antikinetoplastid activity of polyamine–hydroxybenzotriazole conjugates;Bioorganic & Medicinal Chemistry;2017-01
4. Design, synthesis and in vitro antikinetoplastid evaluation of N-acylated putrescine, spermidine and spermine derivatives;Bioorganic & Medicinal Chemistry Letters;2015-01
5. Stable analogues of coenzyme-substrate complex of spermidine/spermine-N 1-acetyltransferase reaction. Synthesis and interaction with the enzyme;Russian Journal of Bioorganic Chemistry;2014-03
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