A stereoselective intramolecular Diels–Alder strategy for the tricyclo[9.3.1.03,8]pentadecane core of aromatic C-ring taxanes
Author:
Publisher
Elsevier BV
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Reference26 articles.
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2. (b) Kingston, D. G. I. Chem. Commun. 2001, 867–880.
3. Enantioselective Total Synthesis of (−)-Taxol
4. Synthesis of Novel Taxoids
5. Nicolaou, K. C.; Claiborne, C. F.; Paulvannan, K.; Postema, M. H. D.; Guy, R. K. Chem. Eur. J. 1997, 3, 399–409. Representative taxane 3a cytotoxicity Ovcar-3, IC50=2.80×10−7 M (Taxol®=6.2×10−10 M), HT-29, IC50=1.29×10−7 M (Taxol®=5.1×10−9 M).
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