Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP

Author:

Aguirre Jose A.,Kehr Jan,Yoshitake Takashi,Liu Fang-Ling,Rivera Alicia,Fernandez-Espinola Sergio,Andbjer Beth,Leo Giuseppina,Medhurst Andrew D.,Agnati Luigi F.,Fuxe Kjell

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference9 articles.

1. Computer-assisted morphometry and microdensitometry of transmitter-identified neurons with special reference to the mesostriatal dopamine pathway. Methodological aspects;Agnati;Acta Physiol. Scand., Suppl.,1984

2. Group I mGluR antagonist AIDA protects nigral DA cells from MPTP-induced injury;Aguirre;NeuroReport,2001

3. Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice;Battaglia;J. Neurosci.,2004

4. Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity;Battaglia;J. Neurosci.,2002

5. Changes in dialysate concentrations of glutamate and GABA in the brain: an index of volume transmission mediated actions?;Del Arco;J. Neurochem.,2003

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