α-Lipoic acid suppresses 6-hydroxydopamine-induced ROS generation and apoptosis through the stimulation of glutathione synthesis but not by the expression of heme oxygenase-1

Author:

Fujita Hirofumi,Shiosaka Masahiko,Ogino Tetsuya,Okimura Yuya,Utsumi Toshihiko,Sato Eisuke F.,Akagi Reiko,Inoue Masayasu,Utsumi Kozo,Sasaki Junzo

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference58 articles.

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2. Stimulation of membrane permeability transition by alpha-lipoic acid and its biochemical characteristics;Aoyama;Physiol. Chem. Phys. Med. NMR,2006

3. Lipoic acid: a multifunctional antioxidant;Bast;Biofactors,2003

4. Pre-treatment with R-lipoic acid alleviates the effects of GSH depletion in PC12 cells: implications for Parkinson's disease therapy;Bharat;Neurotoxicology,2002

5. Molecular pathways involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease;Blum;Prog. Neurobiol.,2001

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