Neuroprotective effects of a novel water-soluble poly(ADP-ribose) polymerase-1 inhibitor, MP-124, in in vitro and in vivo models of cerebral ischemia

Author:

Egi Yasuhiro,Matsuura Shigeru,Maruyama Tomoyuki,Fujio Masakazu,Yuki Satoshi,Akira Toshiaki

Publisher

Elsevier BV

Subject

Developmental Biology,Clinical Neurology,Molecular Biology,General Neuroscience

Reference35 articles.

1. Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase in in vitro and in vivo models of stroke;Abdelkarim;Int. J. Mol. Med.,2001

2. Focal brain ischemia in the rat: methods for reproducible neocortical infarction using tandem occlusion of the distal middle cerebral and ipsilateral common carotid arteries;Brint;J. Cereb. Blood Flow Metab.,1988

3. Physiology and pathophysiology of poly(ADP-ribosyl)ation;Burkle;BioEssay.,2001

4. Reactive oxygen radicals in signaling and damage in the ischemic brain;Chan;J. Cereb. Blood Flow Metab.,2001

5. PARP-1: killer or conspirator? Suicide hypothesis revisited;Chiarugi;Trends Pharmacol. Sci.,2002

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