A phytosphingosine derivative mYG-II-6 inhibits histamine-mediated TRPV1 activation and MRGPRX2-dependent mast cell degranulation

Author:

Adhikari Nisha,Lee Wook-Joo,Park Soojun,Kim Sanghee,Shim Won-SikORCID

Funder

Ministry of Health and Welfare

Korea Health Industry Development Institute

Gachon University

Publisher

Elsevier BV

Reference35 articles.

1. Anti-microbial and -inflammatory activity and efficacy of phytosphingosine: an in vitro and in vivo study addressing acne vulgaris;Pavicic;Int. J. Cosmet. Sci.,2007

2. TRPV1 mediates histamine-induced itching via the activation of phospholipase A2 and 12-lipoxygenase;Shim;J. Neurosci.,2007

3. TRPV1 in Pain and Itch;Li;Adv. Exp. Med. Biol.,2021

4. Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch;Meixiong;Immunity,2019

5. Phytosphingosine derivatives ameliorate skin inflammation by inhibiting NF-kappaB and JAK/STAT signaling in keratinocytes and mice;Kim;J, Invest. Dermatol.,2014

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