A flavonoids compound inhibits osteoclast differentiation by attenuating RANKL induced NFATc-1/c-Fos induction

Author:

Zhang Ke,Lei Jun,He Yuan,Yang Xiaobin,Zhang Zhen,Hao Dingjun,Wang Biao,He Baorong

Funder

China Postdoctoral Science Foundation

Shaanxi State Ministry of Health

Shaanxi Postdoctoral Science Foundation

Shaanxi Social Development Science and Technology

Xi'an social development science and technology project

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference35 articles.

1. Skeletal unloading inhibits the in vitro proliferation and differentiation of rat osteoprogenitor cells;Kostenuik;Am. J. Phys.,1997

2. Macrophage colony-stimulating factor and interleukin-6 release by periprosthetic cells stimulates osteoclast formation and bone resorption;Neale;J. Orthop. Res.,1999

3. Osteoclast differentiation and activation;Boyle;Nature,2003

4. Neonatal changes of osteoclasts in osteopetrosis (op/op) mice defective in production of functional macrophage colony-stimulating factor (M-CSF) protein and effects of M-CSF on osteoclast development and differentiation;Umeda;J. Submicrosc. Cytol. Pathol.,1996

5. The scaffold protein RACK1 mediates the RANKL-dependent activation of p38 MAPK in osteoclast precursors;Lin;Sci. Signal.,2015

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