Rotundarpene inhibits Toll-like receptor 2 activation-induced production of inflammatory mediators in keratinocytes by suppressing the Akt and NF-κB pathways

Author:

Kim Yun Jeong,Jung Eun Byul,Lee Min Sung,Seo Seong Jun,Kim Manh Heun,Lee Min Won,Lee Chung Soo

Funder

BK21plus Skin Barrier Network Human Resources Development Team

National Research Foundation of Korea

Ministry of Education

Korea Healthcare Technology R&D Project, Ministry for Health, Welfare & Family Affairs, Republic of Korea

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference46 articles.

1. The contribution of keratinocytes to the pathogenesis of atopic dermatitis;Pastore;Eur J Dermatol,2006

2. NF-κB links keratinocytes and lymphocytes in the pathogenesis of psoriasis;Tsuruta;Recent Pat Inflamm Allergy Drug Discov,2009

3. The role of microorganisms in atopic dermatitis;Baker;Clin Exp Immunol,2006

4. Toll-like receptors: applications to dermatologic disease;Kang;J Am Acad Dermatol,2006

5. Expression, subcellular localization and cytokinic modulation of Toll-like receptors (TLRs) in normal human keratinocytes: TLR2 up-regulation in psoriatic skin;Begon;Eur J Dermatol,2007

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