Pre-activation of TLR3 enhances the therapeutic effect of BMMSCs through regulation the intestinal HIF-2α signaling pathway and balance of NKB cells in experimental alcoholic liver injury

Author:

Ge Lichao,Chen Dazhi,Chen Wenkai,Cai ChaoORCID,Tao Ying,Ye Shasha,Lin Zhuo,Wang Xiaodong,Li Ji,Xu Lanman,Chen YongpingORCID

Funder

National Natural Science Foundation of China

Zhejiang Provincial Natural Science Foundation

Major Scientific and Technological Special Project in the Thirteen Five-year Plan, China

Early Warning and Intervention to End-stage Liver Disease of Wenzhou

Medical Award Fund, Beijing, China

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference54 articles.

1. Chen, R.C., et al., Lactobacillus rhamnosus GG supernatant promotes intestinal barrier function, balances Treg and TH17 cells and ameliorates hepatic injury in a mouse model of chronic-binge alcohol feeding. Toxicol. Lett., 2016. 241: p. 103–10.

2. Endotoxemia and gut barrier dysfunction in alcoholic liver disease;Rao;Hepatology,2009

3. Alcoholic liver disease: pathogenesis and new therapeutic targets;Gao;Gastroenterology,2011

4. Alcoholic liver disease: pathogenesis, management, and novel targets for therapy;Orman;J. Gastroenterol. Hepatol.,2013

5. Alcoholic liver disease: mechanisms of injury and targeted treatment;Louvet;Nat. Rev. Gastroenterol. Hepatol.,2015

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