Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP-Reference-Cited by-同舟云学术

Roflumilast, type 4 phosphodiesterase inhibitor, attenuates inflammation in rats with ulcerative colitis via down-regulation of iNOS and elevation of cAMP

Published:2018-03 Issue: Volume:56 Page:36-42
ISSN:1567-5769
Container-title:International Immunopharmacology
language:en
Short-container-title:International Immunopharmacology

Author:

El-Ashmawy Nahla E.,Khedr Naglaa F.,El-Bahrawy Hoda A.,El-Adawy Samar A.

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference46 articles.

1. Phosphodiesterase 4 in inflammatory diseases: effects of apremilast in psoriatic blood and in dermal myofibroblasts through the PDE4/CD271 complex;Schafer;Cell. Signal.,2016

2. Advances in targeting cyclic nucleotide phosphodiesterases;Maurice;Nat. Rev. Drug Discov.,2014

3. Phosphodiesterase 4 (PDE4) inhibitors in the treatment of COPD: promising drug candidates and future directions;Parikh;Curr. Med. Chem.,2016

4. Roflumilast reverses polymicrobial sepsis-induced liver damage by inhibiting inflammation in mice;Feng;Lab. Investig.,2017

5. Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease;Rabe;Br. J. Pharmacol.,2011

Cited by 20 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Discovery of novel N2-indazole derivatives as phosphodiesterase 4 inhibitors for the treatment of inflammatory bowel disease;European Journal of Medicinal Chemistry;2024-11

2. Cyclic adenosine 3’, 5’-monophosphate (cAMP) signaling is a crucial therapeutic target for ulcerative colitis;Life Sciences;2024-09

3. MnO2 and roflumilast-loaded probiotic membrane vesicles mitigate experimental colitis by synergistically augmenting cAMP in macrophage;Journal of Nanobiotechnology;2024-05-28

4. Hypersampsonone H attenuates ulcerative colitis via inhibition of PDE4 and regulation of cAMP/PKA/CREB signaling pathway;International Immunopharmacology;2024-02

5. Vitronectin Destroyed Intestinal Epithelial Cell Differentiation through Activation of PDE4-Mediated Ferroptosis in Inflammatory Bowel Disease;Mediators of Inflammation;2023-07-19