Differential effects of agonistic 4-1BB (CD137) monoclonal antibody on the maturation and functions of hypoxic dendritic cells

Author:

Shang Qianwen,Dong Zhaojing,Liu Chunmei,Bai Yang,Guo Chun,Zhang Lining,Wang Qun

Funder

National Natural Science Foundation of China

Shandong Young Scientists Award Fund

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference33 articles.

1. Signals through 4-1BB are costimulatory to previously activated splenic T cells and inhibit activation-induced cell death;Hurtado;J Immunol,1997

2. 4-1BB costimulatory signals preferentially induce CD8+ T cell proliferation and lead to the amplification in vivo of cytotoxic T cell responses;Shuford;J Exp Med,1997

3. New insights into the role of 4-1BB in immune responses: beyond CD8+ T cells;Kwon;Trends Immunol,2002

4. Anti-4-1BB monoclonal antibody enhances rejection of large tumor burden by promoting survival but not clonal expansion of tumor-specific CD8+ T cells;May;Cancer Res,2002

5. Intratumoral injection of interferon-alpha and systemic delivery of agonist anti-CD137 monoclonal antibodies synergize for immunotherapy;Dubrot;Int J Cancer,2011

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