Celastrol ameliorates experimental autoimmune uveitis through STAT3 targeting and gut microenvironment reprofiling
Author:
Funder
Zhejiang Province Natural Science Foundation
Publisher
Elsevier BV
Subject
Pharmacology,Immunology,Immunology and Allergy
Reference59 articles.
1. Uveitis: molecular pathogenesis and emerging therapies;Egwuagu;Front. Immunol.,2021
2. Loss of STAT3 in CD4+ T cells prevents development of experimental autoimmune diseases;Liu;J. Immunol.,2008
3. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1;Amadi-Obi;Nat. Med.,2007
4. STAT3-specific single domain nanobody inhibits expansion of pathogenic Th17 responses and suppresses uveitis in mice;Mbanefo;Front. Immunol.,2021
5. JAK2 and STAT3 polymorphisms in a Han Chinese population with Behcet's disease;Hu;Invest. Ophthalmol. Vis. Sci.,2012
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