Activated intestinal microbiome-associated tryptophan metabolism upregulates aryl hydrocarbon receptor to promote osteoarthritis in a rat model

Author:

Chen Liyile,Huang Zeyu,Li Qianhao,Chen Changjun,Luo Yue,Kang PengdeORCID

Funder

West China Hospital, Sichuan University

Sichuan University

Publisher

Elsevier BV

Subject

Pharmacology,Immunology,Immunology and Allergy

Reference52 articles.

1. Low-grade inflammation as a key mediator of the pathogenesis of osteoarthritis;Robinson;Nat Rev Rheumatol.,2016

2. Does lipopolysaccharide-mediated inflammation have a role in OA?;Huang;Nat Rev Rheumatol.,2016

3. Association of Increased Serum Lipopolysaccharide, But Not Microbial Dysbiosis;Loeser;With Obesity-Related Osteoarthritis. Arthritis Rheumatol.,2022

4. Faecal microbiota transplantation from metabolically compromised human donors accelerates osteoarthritis in mice;Huang;Ann. Rheum. Dis.,2020

5. Fecal metabolomics reveals products of dysregulated proteolysis and altered microbial metabolism in obesity-related osteoarthritis;Rushing;Osteoarthr. Cartil.,2021

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