Pathogenesis, prediction and trials for the prevention of insulin-dependent (type 1) diabetes mellitus1Abbreviations: s.c., subcutaneous; i.p., intraperitoneal; i.v., intravenous; IFA, incomplete Freund's adjuvant; DTP, diphtheria-tetanus-pertussis; LCMV, lymphocytic choriomeningitis virus; GAD, glutamic acid decarboxylase; ICA, islet cell autoantibody; JDF, juvenile diabetes foundation; IAA, insulin autoantibody; GAA, glutamic acid decarboxylase autoantibody; DM, diabetes mellitus; RIA, radioimmunoassay; AA, autoantibody; kD, kilodalton; FPIR, first phase insulin release; IIF, indirect immunofluoresence; IGT, impaired glucose tolerance; OGT, oral glucose tolerance.1