Apolipoprotein E Deficiency Increases Remnant Lipoproteins and Accelerates Progressive Atherosclerosis, But Not Xanthoma Formation, in Gene-Modified Minipigs

Author:

Shim Jeong,Poulsen Christian Bo,Hagensen Mette K.,Larsen Torben,Heegaard Peter M.H.,Christoffersen Christina,Bolund Lars,Schmidt Mette,Liu Ying,Li Juan,Li Rong,Callesen Henrik,Bentzon Jacob F.,Sørensen Charlotte B.

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine

Reference26 articles.

1. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells;Plump;Cell,1992

2. Lipoprotein clearance mechanisms in LDL receptor-deficient “apo-B48- only” and “apo-B100-only” mice;Véniant;J Clin Invest,1998

3. Dual mechanisms for the low plasma levels of truncated apolipoprotein B proteins in familial hypobetalipoproteinemia. Analysis of a new mouse model with a nonsense mutation in the Apob gene;Kim;J Clin Invest,1998

4. Apoprotein E as a lipid transport and signaling protein in the blood, liver, and artery wall;Getz;J Lipid Res,2009

5. Apolipoprotein E-deficient lipoproteins induce foam cell formation by downregulation of lysosomal hydrolases in macrophages;Wu;J Lipid Res,2007

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