Lysosome Inhibition by Mefloquine Preferentially Enhances the Cytotoxic Effects of Tyrosine Kinase Inhibitors in Blast Phase Chronic Myeloid Leukemia-Reference-Cited by-同舟云学术

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Lysosome Inhibition by Mefloquine Preferentially Enhances the Cytotoxic Effects of Tyrosine Kinase Inhibitors in Blast Phase Chronic Myeloid Leukemia

Published:2019-09 Issue:9 Volume:12 Page:1221-1228
ISSN:1936-5233
Container-title:Translational Oncology
language:en
Short-container-title:Translational Oncology

Author:

Lam Yi Hui,Than Hein,Sng Colin,Cheong May Anne,Chuah Charles,Xiang Wei

Funder

Singapore General Hospital Research

National Cancer Center

Academia Medical Research

Agency for Science, Technology and Research

Biomedical Research Council

National Research Foundation Singapore

NMRC

NMRC Centre Grant Programme -Targeted Therapy for Blood Cancer

NMRC Clinician Scientist / Clinician Investigator Salary Support Programme

Duke–NUS Medical School Signature Research Program

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference37 articles.

1. Mechanisms of BCR-ABL in the pathogenesis of chronic myelogenous leukaemia;Ren;Nat Rev Cancer,2005

2. Management of chronic myeloid leukemia in blast crisis;Saussele;Ann Hematol,2015

3. Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival;Hamilton;Blood,2012

4. Molecular-defined clonal evolution in patients with chronic myeloid leukemia independent of the BCR-ABL status;Schmidt;Leukemia,2014

5. Human chronic myeloid leukemia stem cells are insensitive to imatinib despite inhibition of BCR-ABL activity;Corbin;J Clin Invest,2011

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