Low serum mesothelin in pancreatic cancer patients results from retention of shed mesothelin in the tumor microenvironment

Author:

Zhang Xianyu,Yu Yunkai,Peer Cody J.,Landsman RebekahORCID,Skorupan Nebojsa,Cao Liang,Alewine ChristineORCID

Funder

National Cancer Institute

National Institutes of Health

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference25 articles.

1. Isolation and characterization of a monoclonal antibody, K1, reactive with ovarian cancers and normal mesothelium;Chang;Int. J. Cancer,1992

2. Furin is not required for processing of mesothelin precursor protein;Joseph;Biochim. Biophys. Acta Mol. Cell Res.,2021

3. Characterization of the antigen (CAK1) recognized by monoclonal antibody K1 present on ovarian cancers and normal mesothelium;Chang;Cancer Res.,1992

4. Multiple proteases are involved in mesothelin shedding by cancer cells;Liu;Commun. Biol.,2020

5. Mesothelin is shed from tumor cells;Ho;Cancer Epidemiol. Biomarkers Prev.,2006

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