Chiral liquid chromatography resolution and stereoselective pharmacokinetic study of the enantiomers of a novel anticonvulsant, N-(4-chlorophenyl)-1-(4-pyridyl)ethylamine, in rats

Author:

Tao X,Kadaba P.K,Nnane I.P

Publisher

Elsevier BV

Subject

Cell Biology,Clinical Biochemistry,Biochemistry,General Medicine,Analytical Chemistry

Reference7 articles.

1. P.K. Kadaba, Optional resolution of racemic aminoalkylpyridine anticonvulsant and (+)aminoalkylprytidine enantiomers as highly potent orally effective anticonvulsant drugs and excitationory amino acid antagonists, US Patent 6,083,964 (2000).

2. Antiepileptogenic Agents

3. Triazolines XV. Anticonvulsant Profile of ADD 17014, a Potentially Unique 1,2,3-Triazoline Antiepileptic Drug, in Mice and Rats

4. Triazolines—XXVII. Δ2-1,2,3-triazoline anticonvulsants: Novel ‘built-in’ heterocyclic prodrugs with a unique ‘dual-action’ mechanism for impairing excitatory amino acid l-glutamate neurotransmission

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