Granular dot-like staining with MLH1 immunohistochemistry is a clone-dependent artefact

Author:

Dasgupta S.,Ewing-Graham P.C.,Groenendijk F.H.,Stam O.,Biermann K.E.,Doukas M.,Dubbink H.J.,van Velthuysen M.F.,Dinjens W.N.M.,Van Bockstal M.R.

Publisher

Elsevier BV

Subject

Cell Biology,Pathology and Forensic Medicine

Reference15 articles.

1. The utility of immunohistochemical detection of DNA mismatch repair gene proteins;Shia;Virchows Arch.,2004

2. Immunohistochemical evaluation of mismatch repair proteins in colorectal carcinoma: the AIFEG/GIPAD proposal;Remo;Pathologica,2016

3. Role of the clinical pathology laboratory in the evaluation of endometrial carcinomas for Lynch syndrome;Djordjevic;Semin. Diagn. Pathol.,2014

4. Hypermethylation of the hMLH1 promoter in colon cancer with microsatellite instability;Cunningham;Cancer Res.,1998

5. Prognosis of stage II and III colon cancer treated with adjuvant 5-fluorouracil or FOLFIRI in relation to microsatellite status: results of the PETACC-3 trial;Klingbiel;Ann. Oncol.,2015

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