Engineering tyrosine residues into hemoglobin enhances heme reduction, decreases oxidative stress and increases vascular retention of a hemoglobin based blood substitute

Author:

Cooper Chris E.,Silkstone Gary G.A.,Simons Michelle,Rajagopal Badri,Syrett Natalie,Shaik Thoufieq,Gretton Svetlana,Welbourn Elizabeth,Bülow Leif,Eriksson Nélida Leiva,Ronda LucaORCID,Mozzarelli AndreaORCID,Eke Andras,Mathe Domokos,Reeder Brandon J.

Funder

Biotechnology and Biological Sciences Research Council

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference58 articles.

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4. Endothelial dysfunction enhances vasoconstriction due to scavenging of nitric oxide by a hemoglobin-based oxygen carrier;Yu;Anesthesiology,2010

5. Rate of reaction with nitric oxide determines the hypertensive effect of cell-free hemoglobin;Doherty;Nat. Biotechnol.,1998

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