Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms-Reference-Cited by-同舟云学术

Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms

Published:2014-02 Issue: Volume:67 Page:171-187
ISSN:0891-5849
Container-title:Free Radical Biology and Medicine
language:en
Short-container-title:Free Radical Biology and Medicine

Author:

Anwar-Mohamed Anwar,Elshenawy Osama H.,Soshilov Anatoly A.,Denison Michael S.,Chris Le X.,Klotz Lars-Oliver,El-Kadi Ayman O.S.

Funder

Natural Sciences and Engineering Research Council of Canada Discovery

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference48 articles.

1. Regulatory mechanisms of monofunctional and bifunctional anticarcinogenic enzyme inducers in murine liver;Prochaska;Cancer Res,1988

2. Cross-talk between transcription factors AhR and Nrf2: lessons for cancer chemoprevention from dioxin;Hayes;Toxicol. Sci.,2009

3. How knockout mouse lines will be used to study the role of drug-metabolizing enzymes and their receptors during reproduction and development, and in environmental toxicity, cancer, and oxidative stress;Nebert;Biochem. Pharmacol,1997

4. Identification of a novel dioxin-inducible cytochrome P450;Rivera;Mol. Pharmacol.,2002

5. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements;Itoh;Biochem. Biophys. Res. Commun.,1997

Cited by 30 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The role of nuclear factor erythroid 2-related factor 2 (NRF2) in arsenic toxicity;Journal of Environmental Sciences;2025-04

2. Dimethylmonothioarsinic acid (DMMTAV) differentially modulates the expression of AHR-regulated cytochrome P450 1A enzymes in vivo and in vitro;Toxicology Letters;2024-04

3. Exploring aryl hydrocarbon receptor (AhR) as a target for Bisphenol-A (BPA)-induced pancreatic islet toxicity and impaired glucose homeostasis: Protective efficacy of ethanol extract of Centella asiatica;Toxicology;2023-12

4. Arsenic trioxide (ATO) up-regulates cytochrome P450 1A (CYP1A) enzymes in murine hepatoma Hepa-1c1c7 cell line;Environmental Toxicology and Pharmacology;2023-08

5. Arsenic and cancer: Evidence and mechanisms;Advances in Pharmacology;2023