Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O2-• and H2O2
Author:
Publisher
Elsevier BV
Subject
Physiology (medical),Biochemistry
Reference40 articles.
1. SDHD mutations in head and neck paragangliomas result in destabilization of complex II in the mitochondrial respiratory chain with loss of enzymatic activity and abnormal mitochondrial morphology;Douwes Dekker;J. Pathol.,2003
2. Accumulation of Krebs cycle intermeiates and over-expression of HIF1a in tumours which result from germline FH and SDH mutations;Pollard;Hum. Mol. Genet.,2005
3. Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-a prolyl hydroxylase;Selak;Cancer Cell,2005
4. The R22X mutation of the SDHD gene in hereitary paraganglioma abolishes the enzymatic activiy of Complex II in the mitochondrial respiratory chain and activities the hypoxia pathway;Gimenez-Roqueplo;Am. J. Hum. Genet.,2001
5. On the association of succinate dehydrogenase mutations with herediary paraganlioma;Baysal;Trends Endocrinol. Metab.,2003
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