Role of labile iron in the toxicity of pharmacological ascorbate-Reference-Cited by-同舟云学术

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Role of labile iron in the toxicity of pharmacological ascorbate

Published:2015-07 Issue: Volume:84 Page:289-295
ISSN:0891-5849
Container-title:Free Radical Biology and Medicine
language:en
Short-container-title:Free Radical Biology and Medicine

Author:

Du Juan,Wagner Brett A.,Buettner Garry R.,Cullen Joseph J.

Funder

NIH

Medical Research Service, Department of Veterans Affairs

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference48 articles.

1. Ascorbic acid at pharmacologic concentrations selectively kills cancer cells: ascorbic acid as a pro-drug for hydrogen peroxide delivery to tissues;Chen;Proc. Natl. Acad. Sci. USA,2005

2. Ascorbic acid in pharmacologic concentrations: a pro-drug for selective delivery of ascorbate radical and hydrogen peroxide to extracellular fluid in vivo;Chen;Proc. Natl. Acad. Sci. USA,2007

3. Mechanisms of ascorbate-induced cytotoxicity in pancreatic cancer;Du;Clin. Cancer Res.,2010

4. Manganoporhyrins increase ascorbate-induced cytotoxicity by enhancing H2O2 generation;Rawal;Cancer Res.,2013

5. In the absence of catalytic metals, ascorbate does not autoxidize at pH 7: ascorbate as a test for catalytic metals;Buettner;J. Biochem. Biophys. Methods,1988

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