Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents-Reference-Cited by-同舟云学术

Metformin induces microRNA-34a to downregulate the Sirt1/Pgc-1α/Nrf2 pathway, leading to increased susceptibility of wild-type p53 cancer cells to oxidative stress and therapeutic agents

Published:2014-09 Issue: Volume:74 Page:21-34
ISSN:0891-5849
Container-title:Free Radical Biology and Medicine
language:en
Short-container-title:Free Radical Biology and Medicine

Author:

Truong Do Minh,Gyun Kim Hyung,Ho Choi Jae,Gwang Jeong Hye

Funder

Basic Science Research Program through the National Research Foundation of Korea

Ministry of Science, ICT, and Future Planning

Ministry of Education, Science, and Technology

Publisher

Elsevier BV

Subject

Physiology (medical),Biochemistry

Reference56 articles.

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4. hSIR2 (SIRT1) functions as an NAD-dependent p53 deacetylase;Vaziri;Cell,2001

5. SIRT1 controls the transcription of the peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PGC-1alpha) gene in skeletal muscle through the PGC-1alpha autoregulatory loop and interaction with MyoD;Amat;J. Biol. Chem.,2009

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