Modeling the freezing process of aqueous solutions considering thermal gradients and stochastic ice nucleation

Author:

Deck Leif-ThoreORCID,Košir AndražORCID,Mazzotti MarcoORCID

Publisher

Elsevier BV

Reference49 articles.

1. Understanding the freezing of biopharmaceuticals: First-principle modeling of the process and evaluation of its effect on product quality;Radmanovic;J. Pharm. Sci.,2013

2. Current perspectives on stability of protein drug products during formulation, fill and finish operations;Rathore;Biotechnol. Prog.,2008

3. Freezing of biologicals revisited: Scale, stability, excipients, and degradation stresses;Authelin;J. Pharm. Sci.,2020

4. Protein stability during freezing: Separation of stresses and mechanisms of protein stabilization;Bhatnagar;Pharm. Dev. Technol.,2007

5. The impact of the freezing stage in lyophilization: Effects of the ice nucleation temperature on process design and product quality;Pikal;Am. Pharm. Rev.,2002

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