Leptin-depended NLRP3 inflammasome activation in osteoarthritic chondrocytes is mediated by ROS

Author:

Mourmoura Evanthia,Papathanasiou Ioanna,Trachana Varvara,Konteles Vasilis,Tsoumpou Alexandra,Goutas Andreas,Papageorgiou Aliki-Alexandra,Stefanou Nikolaos,Tsezou Aspasia

Funder

European Regional Development Fund

University of Thessaly

European Commission

Publisher

Elsevier BV

Subject

Developmental Biology,Aging

Reference100 articles.

1. Intra-articular injection of baicalein inhibits cartilage catabolism and NLRP3 inflammasome signaling in a posttraumatic OA Model;Bai;Oxid. Med. Cell. Longev.,2021

2. Leptin plays a catabolic role on articular cartilage;Bao;Mol. Biol. Rep.,2010

3. Stress-induced cartilage degradation does not depend on the NLRP3 inflammasome in human osteoarthritis and mouse models;Bougault;Arthritis Rheum.,2012

4. Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain;Bryan;J. Immunol.,2009

5. MicroRNA-34a and MicroRNA-181a mediate visfatin-induced apoptosis and oxidative stress via nf-κb pathway in human osteoarthritic chondrocytes;Cheleschi;Cells,2019

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