Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System-Reference-Cited by-同舟云学术

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Rapid Characterization of hERG Channel Kinetics I: Using an Automated High-Throughput System

Published:2019-12 Issue:12 Volume:117 Page:2438-2454
ISSN:0006-3495
Container-title:Biophysical Journal
language:en
Short-container-title:Biophysical Journal

Author:

Lei Chon Lok,Clerx Michael,Gavaghan David J.,Polonchuk Liudmila,Mirams Gary R.,Wang Ken

Funder

Wellcome Trust

Engineering and Physical Sciences Research Council

Medical Research Council

Biotechnology and Biological Sciences Research Council

Clarendon Scholarship Fund

F. Hoffman-LaRoche Ltd

Royal Society

Publisher

Elsevier BV

Subject

Biophysics

Reference29 articles.

1. A mechanistic link between an inherited and an acquired cardiac arrhythmia: HERG encodes the IKr potassium channel;Sanguinetti;Cell,1995

2. Rate-dependent prolongation of cardiac action potentials by a methanesulfonanilide class III antiarrhythmic agent. Specific block of rapidly activating delayed rectifier K+ current by dofetilide;Jurkiewicz;Circ. Res,1993

3. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling;Malik;Drug Saf,2001

4. Non-clinical evaluation of ventricular repolarization (ICH S7B): results of an interim survey of international pharmaceutical companies;Friedrichs;J. Pharmacol. Toxicol. Methods,2005

5. Simulation of multiple ion channel block provides improved early prediction of compounds’ clinical torsadogenic risk;Mirams;Cardiovasc. Res,2011

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