Cryo-EM catalyzes the exploration of drug selectivity: The CDK7 inhibitor example
Author:
Funder
National Institutes of Health
Publisher
Elsevier BV
Subject
Biophysics
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2. TFIIH-associated Cdk7 kinase functions in phosphorylation of C-terminal domain Ser7 residues, promoter-proximal pausing, and termination by RNA polymerase II;Glover-Cutter;Mol. Cell. Biol,2009
3. Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II;Larochelle;Nat. Struct. Mol. Biol,2012
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1. Design and Synthesis of Novel Macrocyclic Derivatives as Potent and Selective Cyclin-Dependent Kinase 7 Inhibitors;Journal of Medicinal Chemistry;2024-04-08
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