Revalidation of the in vitro alkaline elution/rat hepatocyte assay for DNA damage: improved criteria for assessment of cytotoxicity and genotoxicity and results for 81 compounds

Author:

Storer Richard D.,McKelvey Troy W.,Kraynak Andrew R.,Elia Michael C.,Barnum John E.,Harmon Lori S.,Nichols Warren W.,DeLuca John G.

Publisher

Elsevier BV

Subject

Genetics,Toxicology

Reference47 articles.

1. Radiation induced strand breakage in DNA from mammalian cells. Strand separation in alkaline solution;Ahnstrom;Int. J. Radial. Biol.,1973

2. A quantitative assessment of the cytotoxicity associated with chromosomal aberration detection in Chinese hamster ovary cells;Armstrong;Mutation Res.,1992

3. Methods for detecting carcinogens and mutagens with the alkaline elution/rat hepatocyte assay;Bradley,1984

4. Measurements by filter elution of DNA single-and double-strand breaks in rat hepatocytes: Effects of nitrosamines and gamma irradiation;Bradley;Cancer Res.,1982

5. Relationships among cytotoxicity, lysosomal breakdown, chromosome aberrations and DNA double-strand breaks;Bradley;Mutation Res.,1987

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