Cytotoxicity, genotoxicity and transforming activity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in rat tracheal epithelial cells

Author:

Zhu Songyun,Cunningham Michael L.,Gray Thomas E.,Nettesheim Paul

Publisher

Elsevier BV

Subject

Genetics,Toxicology

Reference37 articles.

1. In vitro genotoxicity of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone activated by hamster maternal and fetal tissues;Alaoui-Jamali;Carcinogenesis,1988

2. Transplacental genotoxicity of a tobacco-specific N-nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, in Syrian golden hamster;Alaoui-Jamali;Mutation Res.,1989

3. Accumulation and persistence of DNA adducts in respiratory tissue of rats following multiple administrations of the tobacco specific carcinogen 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone;Belinsky;Cancer Res.,1986

4. Molecular dosimetry of DNA adduct formation and cell toxicity in rat nasal mucosa following exposure to the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone and their relationship to induction of neoplasia;Belinsky;Cancer Res.,1987

5. Cell specific differences in O6-methylguanine-DNA methyltransferase activity and removal of O6-methylguanine in rat pulmonary cells;Belinsky;Carcinogenesis,1988

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