Involvement of CYP3A4/5 and CYP2D6 in the metabolism of aconitine using human liver microsomes and recombinant CYP450 enzymes

Author:

Tang Lan,Ye Ling,Lv Chang,Zheng Zhijie,Gong Yun,Liu Zhongqiu

Funder

the National Basic Research Program of China

Project of National Natural Science Foundation of China

the Key Project of National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference25 articles.

1. The effects of Aconitum alkaloids on the central nervous system;Ameri;Prog. Neurobiol.,1998

2. Thalidomide metabolism by the CYP2C subfamily;Ando;Clin. Cancer Res.,2002

3. The use of in vitro methods to predict in vivo pharmacokinetics and drug interactions;Bachmann;Curr. Drug Metab.,2001

4. Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes;Catterall;Annu. Rev. Pharmacol. Toxicol.,1980

5. Herb-induced aconitine poisoning presenting as tetraplegia;Chan;Vet. Hum. Toxicol.,1994

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