An overview of the current challenges when using rabbits for prenatal developmental toxicity studies with consideration of the impact on data interpretation

Author:

Moxon MaryORCID,Beekhuijzen Manon,Hannas Bethany,Manton Jason,French Julian,Malley Linda

Publisher

Elsevier BV

Subject

Toxicology

Reference58 articles.

1. OECD (2018). Test No. 414: Prenatal Developmental Toxicity Study, OECD Guidelines for the Testing of Chemicals, Section 4, OECD Publishing, Paris. https://doi.org/10.1787/9789264070820-en.

2. EPA (1998). Health Effects Test Guidelines: OPPTS 870.3700 Prenatal Developmental Toxicity Study [EPA 712–C–98–207].

3. ICH S5(R3), (2020). International Council for Harmonisation of technical requirements for pharmaceuticals for human use. ICH harmonised guideline S5(R3). Detection of reproductive and developmental toxicity for human pharmaceuticals. Adopted on 18 February 2020. https://www.ich.org/page/safety-guidelines.

4. Use of the Rabbit in Teratogenicity Studies;Gibson;Toxicol. Appl. Pharmacol.,1966

5. Hafez, E.S.E. (1970). Rabbits. In "Reproduction and Breeding Techniques for Laboratory Animals" (E. S. H. Hafez, ed.), p. 274. Lea & Febiger, Philadelphia, Pennsylvania, USA.

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