Assessment of the genotoxic and carcinogenic risks of p-nitrophenol when it is present as an impurity in a drug product

Author:

Eichenbaum G.,Johnson M.,Kirkland D.,O’Neill P.,Stellar S.,Bielawne J.,DeWire R.,Areia D.,Bryant S.,Weiner S.,Desai-Krieger D.,Guzzie-Peck P.,Evans David C.,Tonelli A.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference34 articles.

1. Mutagenic evaluation of carcinogens and non-carcinogens in the L5178Y/TK assay utilizing postmitochondrial fractions (S9) from normal rat liver;Amacher;Mutat. Res.,1982

2. ATDSR, 1992. Toxicological profile for nitrophenols: 2-nitrophenol, 4-nitrophenol. Agency for Toxic Substances and Disease Registry US Public Health Service. http://www.atsdr.cdc.gov/toxprofiles/tp50.pdf.

3. Mutagenicity investigations with pesticides in the host-mediated assay and the dominant lethal test in mice;Buselmaier;Biol. Zentralbl.,1972

4. Commoner, B., 1976. Reliability of bacterial mutagenesis techniques to distinguish carcinogenic and noncarcinogenic chemicals.

5. Physiological parameters in laboratory animals and humans;Davies;Pharm. Res.,1993

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