Strategies for the optimisation of in vivo experiments in accordance with the 3Rs philosophy

Author:

Madden Judith C.,Hewitt Mark,Przybylak Katarzyna,Vandebriel Rob J.,Piersma Aldert H.,Cronin Mark T.D.

Funder

EU FP6 OSIRIS Project

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference80 articles.

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2. Article 13 (4), 2006. Regulation (EC) No. 1907/2006 of the European Parliament and of the Council concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH). Available from: .

3. Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?;Benigni;Expert. Opin. Drug Metab. Toxicol. 8,2012

4. Skin sensitisation – a critical review of predictive test methods in animals and man;Botham;Fd. Chem. Toxic.,1991

5. Integrated decision-tree testing strategies for mutagenicity and carcinogenicity with respect to the requirements of the EU REACH legislation;Combes;ATLA,2007

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