Inflammation and immunogenicity limit the utility of the rabbit as a nonclinical species for ocular biologic therapeutics

Author:

de Zafra Christina L.ZuchORCID,Sasseville Vito G.,Matsumoto Steven,Freichel Christian,Milton Mark,MacLachlan Timothy K.,Farman Cindy,Raymond Iona,Gupta Swati,Newton Ronald,Atzpodien Elke-Astrid,Thackaberry Evan A.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference41 articles.

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3. Lucentis™, Ranibizumab Pharmacology/Toxicology Review and Evaluation;CDER (Center for Drug Evaluation and Research),2006

4. Pharmaceutical toxicology: designing studies to reduce animal use, while maximizing human translation;Chapman;Reg. Tox. Pharm.,2013

5. Mechanisms of leukocyte migration across the blood-retina barrier;Crane;Semin. Immunopathol.,2008

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