Detection of antibodies against therapeutic proteins in the presence of residual therapeutic protein using a solid-phase extraction with acid dissociation (SPEAD) sample treatment prior to ELISA

Author:

Smith Holly W.,Butterfield Anthony,Sun Deqin

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference15 articles.

1. Influence of immunogenicity on the long-term efficacy of infliximab in Chron’s disease;Baert;N. Engl. J. Med.,2003

2. Removal of therapeutic anti-lymphocyte antibodies from human sera prior to anti-human leukocyte antibody testing;Bearden;J. Immunol. Methods,2005

3. Predictive power of preclinical studies in animals for the immunogenicity of recombinant therapeutic proteins in humans;Bugelski;Curr. Opin. Mol. Ther.,2004

4. Monoclonal antibodies, immunogenicity, and associated infusion reactions;Cheifetz;Mt. Sinai. J. Med.,2005

5. European Medicines Agency (EMEA), Committee for Medicinal Products for Human Use (CHMP). Guideline on immunogenicity assessment of biotechnology-derived therapeutic proteins. EMEA/CHMP/BMWP/14327/2006. .

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