A nonclinical safety and pharmacokinetic evaluation of N6022: A first-in-class S-nitrosoglutathione reductase inhibitor for the treatment of asthma

Author:

Colagiovanni Dorothy B.,Drolet Daniel W.,Langlois-Forget Emilie,Piché Marie-Pier,Looker Doug,Rosenthal Gary J.

Publisher

Elsevier BV

Subject

Toxicology,General Medicine

Reference38 articles.

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2. Oral S-nitrosoglutathione reductase inhibitors attenuate pulmonary inflammation and decrease airspace enlargement in experimental models of chronic obstructive pulmonary disease;Blonder;Am. J. Respir. Crit. Care Med.,2011

3. Idiosyncratic liver toxicity of nonsteroidal anti-inflammatory drugs: molecular mechanisms and pathology;Boelsterli;Crit. Rev. Toxicol.,1995

4. Liatest, a new fast assay to determine D-dimers, has performances comparable to classical ELISA for diagnosis of deep vein thrombosis;Boneu;Thromb. Haemost.,1997

5. Recommended tissue list for histopathologic examination in repeat-dose toxicity and carcinogenicity studies: a proposal of the society of toxicologic pathology (STP);Bregman;Toxicol. Pathol.,2003

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